氰甲基磷酸二乙酯

Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.

Incompatible with acids, bases, oxidizing agents and reducing agents.

MFCD00001893

219-806-0

C₆H₁₂NO₃P

177.14

132-135°/1.2mm

>110°(230°F)

1.094

1.4330

Ambient temperatures.

Liquid

Miscible with water, chloroform, terahydrofuran, ethyl acetate and methylene chloride.

1772981

III

20/21/22-36/38
Harmful by inhalation, in contact with skin and if swallowed.Irritating to eyes and skin.

6.1

9-23-26-36/37-60
Keep container in a well-ventilated place.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste

 

否

 

H302-H312-H331-H315-H319
Harmful if swallowed.Harmful in contact with skin.Toxic if inhaled.Causes skin irritation.Causes serious eye irritation.

P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.