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Cyclothiazide

产品编号:3073706
CAS NO:2259-96-3
包装规格:10 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
307370610 MG1370
307370625 MG3540
产品别名

2259-96-3

Cyclothiazide

6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C14H16ClN3O4S2
Molecular weight
389.88
EC number【EC 号】
218-859-7
MDL number
MFCD00210192
PubChem Substance ID【PubChem化学物质编号】
24278350
NACRES
NA.77
General description【一般描述】
Cyclothiazide is a benzothiadiazine, which has a similar structure to diazoxide.
Application【应用】
Cyclothiazide has been used as a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) desensitization blocker to study the effects of γ2 on receptor desensitization.
Biochem/physiol Actions【生化/生理作用】
Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.
Features and Benefits【特点和优势】
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
产品性质
Quality Level【质量水平】
200
originator【创始人】
Eli Lilly
storage temp.【储存温度】
2-8℃
SMILES string
[H][C@@]12CC(C3Nc4cc(Cl)c(cc4S(=O)(=O)N3)S(N)(=O)=O)[C@@]([H])(C1)C=C2
InChI
1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1
InChI key
BOCUKUHCLICSIY-QJWLJZLASA-N
Gene Information
human ... CA1(759), CA4(762), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
rat ... Gria1(50592)
packaging【包装】
10 mg in poly bottle
25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 2
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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