脱氧胆酸

C₂₄H₄₀O₄

392.57

3219882

201-478-5

MFCD00003673

329753610

NA.77

Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.

Deoxycholic acid has been used as:

• a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract
• an internal standard to estimate the toxin concentration in the cell pellet
• a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry

Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body. High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.

用于β-肾上腺素能受体的增溶

100

ox bile

anionic

≥99.0% (T)

powder

[α]20/D +54±1°, c = 1% in ethanol

392.57 g/mol

≤1% cholic acid (TLC)

170-175 ℃
171-174 ℃ (lit.)

carboxylic acid

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

KXGVEGMKQFWNSR-LLQZFEROSA-N

human ... ATIC(471)

GHS07

Warning

H302

P301 + P312 + P330

Acute Tox. 4 Oral

13 - Non Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves