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脱羟基 LY-411575
Deshydroxy LY-411575
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3075077 | 5 MG | 1550 | |||
| 3075077 | 25 MG | 4550 |
产品别名
209984-56-5
脱羟基 LY-411575
Deshydroxy LY-411575
Dibenzazepine
YO-01027
(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide
GSI-XX
N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide
DBZ
γ-Secretase inhibitor XX
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H23F2N3O3 |
| Molecular weight | 463.48 |
| NACRES | NA.77 |
| Application【应用】 | Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment. |
| Biochem/physiol Actions【生化/生理作用】 | LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein. Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC50 of 1.7 nM in SupT1 cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 15 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
