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DK-AH 269
| 产品编号： | 3078850 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 186097-54-1 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
186097-54-1
DK-AH 269
Cilobradine hydrochloride
(S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
cilobradine 盐酸盐
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H38N2O5 · HCl |
| Molecular weight | 519.07 |
| MDL number | MFCD07776908 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724467 |
| NACRES | NA.77 |
| Application【应用】 | DK-AH 269 has been used as a hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) antagonist to study its effects on the inhibition of Ih in HCN-deficient hair cells of mice. It has also been used as an HCN blocker to study its effects on action potential firing in the suprachiasmatic nucleus (SCN) neurons. |
| Biochem/physiol Actions【生化/生理作用】 | DK-AH 269 is a bradycardiac agent. DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white |
| solubility【溶解性】 | H2O: ~20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1CC2=CC(OC)=C(OC)C=C2CCN1C[C@@H](CCC3)CN3CCC4=CC(OC)=C(OC)C=C4.[H]Cl |
| InChI | 1S/C28H38N2O5.ClH/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31;/h7-8,14-16,21H,5-6,9-13,17-19H2,1-4H3;1H/t21-;/m0./s1 |
| InChI key | MTAKUIYCCYKGJJ-BOXHHOBZSA-N |
| packaging【包装】 | 5 mg in glass bottle 25 mg in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
