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DTME (dithio-bis-maleimidoethane)

产品编号:3080020
CAS NO:71865-37-7
包装规格:50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
308002050 MG3670
产品别名

71865-37-7

DTME (dithio-bis-maleimidoethane)

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C12H12N2S2O4
Molecular weight
312.36
MDL number
MFCD01863385
PubChem Substance ID【PubChem化学物质编号】
329768821
NACRES
NA.22
General description【一般描述】
DTME is a homobifunctional, maleimide crosslinker for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. DTME is similar in length to BMH but differs in containing a disulfide bond in its spacer arm, allowing crosslinks with DTME to be cleaved with reducing agent such as dithiothreitol (DTT).
Features and Benefits【特点和优势】
  • Reactive groups: maleimide (both ends)
  • Reactive towards: sulfhydryl groups
  • Long (13.3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
  • Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
  • Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agent
Caution【注意】
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥90%
form【形式】
powder
mol wt【分子量】
312.37
reaction suitability
reagent type: cross-linking reagent
storage condition【储存条件】
desiccated
solubility【溶解性】
DMSO or DMF: soluble
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
SMILES string
O=C(C=CC1=O)N1CCSSCCN2C(C=CC2=O)=O
InChI
1S/C12H12N2O4S2/c15-9-1-2-10(16)13(9)5-7-19-20-8-6-14-11(17)3-4-12(14)18/h1-4H,5-8H2
InChI key
SGVWDRVQIYUSRA-UHFFFAOYSA-N
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302 + H312 + H332 - H315 - H319 - H335
Precautionary Statements
P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
Hazard Classifications【危险分类】
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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