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FOLR1 from mouse
产品编号: | 3089033 |
规格: | recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) |
包装规格: | 10 μG,50 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
FOLR1 from mouse
Folate receptor-alpha
FBP
FOLR-1
FOLR
基本信息
NACRES | NA.32 |
General description【一般描述】 | Folate Receptor 1 (FOLR1) also known as Folate receptor α, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. |
Physical form【外形】 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃. |
产品性质
biological source【生物来源】 | mouse |
recombinant【重组】 | expressed in HEK 293 cells |
tag【标签】 | 6-His tagged (C-terminus) |
Assay【测定】 | ≥95% (SDS-PAGE) |
form【形式】 | lyophilized |
mol wt【分子量】 | calculated mol wt 25.6 kDa observed mol wt 45-50 kDa by SDS-PAGE (DTT-reduced. Protein migrates due to glycosylation. Thr 25 is the predicted N-terminal.) |
packaging【包装】 | pkg of 10 and 50 μg |
impurities【杂质】 | <1 EU/μg endotoxin (LAL test) |
UniProt accession no.【UniProt登记号】 | P35846 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | mouse ... FOLR1(14275) |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |