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Fostriecin sodium salt from Streptomyces pulveraceus

产品编号:3089220
规格:≥98% (HPLC)
CAS NO:87860-39-7
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
308922010 μG5660
产品别名

87860-39-7

Fostriecin sodium salt from Streptomyces pulveraceus

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C19H26NaO9P
Molecular weight
452.37
MDL number
MFCD09971059
PubChem Substance ID【PubChem化学物质编号】
24894863
Application【应用】
Fostriecin has been used as a protein phosphatases type 2A (PP2A) inhibitor to study its effects on phosphorylated myosin light chain (pMLC) levels in axon initial segments (AIS). It has also been used as a PP2A inhibitor to study its effects on the regulation of protein kinase Akt (pAKT) by dopamine (DA) in larval zebrafish brain.
Biochem/physiol Actions【生化/生理作用】
Fostriecin is a natural inhibitor of serine/ threonine phosphatases. It is a phosphate monoester produced by fermentation beer of Streptomyces pulveraceus. Fostriecin is a strong inhibitor of protein phosphatases type 2A and 4 (PP2A and PP4) and a weak inhibitor of protein phosphatases type 1 and 5 (PP1 and PP5). It exhibits anti-tumor activity against several tumor cells in vitro and L1210 and P388 leukemias in vivo. The anti-tumor activity of fostriecin is due to its ability to interfere with the reversible phosphorylation of proteins that are involved in the progression of the cell cycle. It also exhibits cytotoxic effects. Fostriecin can inhibit the DNA, RNA and protein synthesis.
Features and Benefits【特点和优势】
This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
biological source【生物来源】
Streptomyces sp. (Streptomyces pulveraceous)
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
solubility【溶解性】
ethanol: soluble
methanol: soluble
water: soluble
storage temp.【储存温度】
−20℃
SMILES string
[Na+].C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)([O-])=O
InChI
1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1/b3-2-,6-4+,8-5-,12-11+;/t15-,16+,17+,19+;/m0./s1
InChI key
XBUIKNRVGYFSHL-IAVQPKKASA-M
packaging【包装】
10 μg in glass insert
在氩气下包装。
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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