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FQI1
产品别名
599151-35-6
FQI1
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H17NO4 |
| Molecular weight | 311.33 |
| MDL number | MFCD03632583 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825408 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL (clear solution) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1 |
| InChI | 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20) |
| InChI key | YKSYGLXHLSPWLB-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
