3,5-二甲基-1-碘苯

(CH₃)₂C₆H₃I

232.06

MFCD00060659

24864461

NA.22

1-Iodo-3,5-dimethylbenzene (5-Iodo-m-xylene) is an aryl halide. It can be obtained from 5-bromo-m-xylene, via copper-catalyzed halogen exchange reaction, in the presence of NaI or KI in n-BuOH or DMF (solvents). It undergoes reaction with phenol in the presence of CuFe₂O₄ nano powder as a recyclable catalyst to afford 1,3-dimethyl-5-phenoxybenzene.

1-Iodo-3,5-dimethylbenzene (5-iodo-m-xylene) is suitable for use in the synthesis of N-(3,5-xylyl)-N-ethylaniline, an arylamine.
It may be used in the following studies:

• α-Arylation of ketones.
• Copper-catalyzed N-arylation of imidazoles.
• Cyanation of 5-iodo-m-xylene to form 3,5-dimethylbenzonitrile.
• Synthesis of 1,3-Dimethyl-5-phenoxybenzene by nano-CuFe₂O₄ catalyzed C-O cross-coupling with phenol.
• CuBr-catalyzed amination of 1-iodo-3,5-dimethylbenzene to form N-Allyl-3,5-dimethylbenzenamine.
• Copper-catalyzed C-S bond-formation between 5-iodo-m-xylene and thiophenol.
• As a starting material in the synthesis of biphenyl-3,3′,5,5′-tetracarboxylic acid.
• Radical bromination of 5-iodo-m-xylene by N-bromosuccinimide to form 1,3-bis(bromomethyl)-5-iodobenzene.

100

99%

n20/D 1.594 (lit.)

92-94 ℃/3 mmHg (lit.)

1.608 g/mL at 25 ℃ (lit.)

Cc1cc(C)cc(I)c1

1S/C8H9I/c1-6-3-7(2)5-8(9)4-6/h3-5H,1-2H3

ZLMKEENUYIUKKC-UHFFFAOYSA-N

5, 25 mL in glass bottle

GHS07

Warning

H315 - H319 - H335

P302 + P352 - P305 + P351 + P338

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

10 - Combustible liquids

WGK 3

235.4 °F - closed cup

113 ℃ - closed cup

Eyeshields, Gloves, type ABEK (EN14387) respirator filter