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I-BRD9

产品编号:3097965
规格:≥98% (HPLC)
CAS NO:1714146-59-4
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
30979655 MG2010
309796525 MG7050
产品别名

1714146-59-4

I-BRD9

N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyridine-2-carboximidamide

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C22H22F3N3O3S2
Molecular weight
497.55
MDL number
MFCD28952791
PubChem Substance ID【PubChem化学物质编号】
329825949
NACRES
NA.77
General description【一般描述】
I-BRD9 is developed from thienopyridone scaffold. It can also be used as an identifier for BRD9 regulated gene in Kasumi-1 cells involved in oncology and immune response pathways.
Biochem/physiol Actions【生化/生理作用】
I-BRD9 is a selective cellular chemical probe for bromodomain-containing protein 9 (BRD9), thought to be a member of the chromatin remodelling SWI/SNF BAF complex, which plays a fundamental role in gene expression regulation. I-BRD9 has a pIC50 value of 7.3 with greater than 700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7) and greater than 70-fold selectivity against a panel of 34 bromodomains. For full characterization details, please visit the I-BRD9 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits【特点和优势】
I-BRD9 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Other Notes【其他说明】
I-BRD9 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the I-BRD9 probe summary on the Chemical Probes Portal website.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to beige
solubility【溶解性】
DMSO: 20 mg/mL, clear
storage temp.【储存温度】
−20℃
SMILES string
CCN1C(C2=C(SC(C(NC3CCS(CC3)(=O)=O)=N)=C2)C(C4=CC(C(F)(F)F)=CC=C4)=C1)=O
InChI
1S/C22H22F3N3O3S2/c1-2-28-12-17(13-4-3-5-14(10-13)22(23,24)25)19-16(21(28)29)11-18(32-19)20(26)27-15-6-8-33(30,31)9-7-15/h3-5,10-12,15H,2,6-9H2,1H3,(H2,26,27)
InChI key
WRUWGLUCNBMGPS-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Pictograms【象形图】
GHS06
Signal word【警示用语:】
Danger
Hazard Statements
H301
Precautionary Statements
P301 + P330 + P331 + P310
Hazard Classifications【危险分类】
Acute Tox. 3 Oral
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
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