异维A酸

C₂₀H₂₈O₂

300.44

MFCD00079542

329815327

NA.24

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Isotretinoin, a vital isomer of vitamin A, is implicated in the treatment of severe recalcitrant nodular acne disorder. It is the only drug known to operate against the major pathogenic factors of acne. It serves to diminish the sebaceous gland activity, thereby resulting in the correction of keratinization defect.

Isotretinoin may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

13- 顺 -维甲酸 (RA) 具有抗炎和抗肿瘤操作。RA 的操作是通过 RAR-β 介导的和 RAR-α受体。RA 可减弱细胞因子刺激的小鼠系膜细胞 iNOS 的表达和活性。它诱导线粒体膜通透性转换，观察为肿胀和膜电位降低，并通过细胞凋亡途径刺激细胞色素 c 的释放牵连机制。这些活动被 EGTA 和环孢霉素 A 逆转。RA 也部分通过增加转录增加 MMP-1 蛋白表达。

Please find SDS provided by EDQM here..

Sales restrictions may apply.

synthetic

pharmaceutical primary standard

EP

solid

EDQM

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

172-175 ℃ (lit.)

pharmaceutical (small molecule)

neat

[H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-

SHGAZHPCJJPHSC-XFYACQKRSA-N

human ... RARA(5914), RARB(5915), RARG(5916)

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

GHS07,GHS08

Danger

H315 - H319 - H335 - H360

P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Respiratory system

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3