L48H37

产品编号：

3104044

规格：	≥98% (HPLC)

包装规格：

5 MG，25 MG

产品类别：

进口试剂

品牌：	Sigma-Aldrich

优惠价：

产品价格

产品别名

L48H37

1-Ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylene]-4-piperidinone

(3E,5E)-1-ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylidene]piperidin-4-one

1-Ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one

结构式

基本信息

Empirical Formula【经验(实验)分子式】	C₂₇H₃₃NO₇
Molecular weight	483.55
PubChem Substance ID【PubChem化学物质编号】	329825883
NACRES	NA.77
Application【应用】	L48H37 has been used as a myeloid differentiator protein 2 (MD2) antagonist/inhibitor: to investigate intracellular signaling of LPS in signal transduction pathways via endosomic toll-like receptor 4 (TLR4) in colonic epithelium to determine its anti-cancer effects in pancreatic ductal adenocarcinoma (PDAC) to study its effects on lipopolysaccharide (LPS) and palmitate CC chemokine ligand 2 (CCL2) responses in normal kidney proximal tubule cells
Biochem/physiol Actions【生化/生理作用】	L48H37 can stimulate apoptosis and prevent proliferation in pancreatic cancer cells, especially in the absence of histone-lysine N-methyltransferase 2D (KMT2D). It has an unsaturated monoketone structure, which helps to enhance its stability and anti-cancer effects. L48H37 may possess an anti-neoplastic effect on human pancreatic ductal adenocarcinoma (PDAC) cells. L48H37 is a potent and chemically stable anti-inflammatory curcumin analog that inhibits LPS-induced inflammation through the myeloid differentiation 2 (MD-2) and toll-like receptor 4 (TLR4) complex. L48H37 is a potent MD2 inhibitor that binds to the hydrophobic region of MD-2 and blocks the interaction between MD2 and LPS. L48H37 significantly improves survival and protected lung injury in LPS-induced septic mice.

产品性质

Quality Level【质量水平】	100
Assay【测定】	≥98% (HPLC)
form【形式】	powder
color【颜色】	white to beige
solubility【溶解性】	DMSO: 2 mg/mL, clear (warmed)
storage temp.【储存温度】	2-8℃
SMILES string	O=C(/C(CN(CC)C/1)=C/C2=C(OC)C(OC)=C(OC)C=C2)C1=C\C3=CC=C(OC)C(OC)=C3OC
InChI	1S/C27H33NO7/c1-8-28-15-19(13-17-9-11-21(30-2)26(34-6)24(17)32-4)23(29)20(16-28)14-18-10-12-22(31-3)27(35-7)25(18)33-5/h9-14H,8,15-16H2,1-7H3/b19-13+,20-14+
InChI key	XLPNFINERWLGNC-IWGRKNQJSA-N
packaging【包装】	5, 25 mg in glass bottle

安全信息

Storage Class Code【储存分类代码】	13 - Non Combustible Solids
WGK	WGK 3

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