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LP 12 盐酸盐 水合物
LP 12 hydrochloride hydrate
产品别名
LP 12 盐酸盐 水合物
LP 12 hydrochloride hydrate
4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1- piperazinehexanamide hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C32H39N3O·HCl · xH2O |
| Molecular weight | 518.13 (anhydrous basis) |
| MDL number | MFCD11114387 |
| PubChem Substance ID【PubChem化学物质编号】 | 329817403 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | LP 12 dihydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and 1464 nM, respectively. It also displays selectivity over D2, 1723; over 5-HT1A, 468; over 5-HT2A, 11261; and high potency. Sigma has added LP 44 (L9793) which shows significantly lower D2 selectivity (7.3 nM/0.22 nM for 33-fold), lower selectivity over 5-HT1A, 240; and over 5-HT2A, 1482. LP 12 and LP 44 seem to share a common intermediate. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: >5 mg/mL H2O: 6 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O.Cl.O=C(CCCCCN1CCN(CC1)c2ccccc2-c3ccccc3)NC4CCCc5ccccc45 |
| InChI | 1S/C32H39N3O.ClH.H2O/c36-32(33-30-18-11-15-26-14-6-7-16-28(26)30)20-5-2-10-21-34-22-24-35(25-23-34)31-19-9-8-17-29(31)27-12-3-1-4-13-27;;/h1,3-4,6-9,12-14,16-17,19,30H,2,5,10-11,15,18,20-25H2,(H,33,36);1H;1H2 |
| InChI key | VOKWUIAIZYWMDR-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
