您的位置:首页 > 产品中心 > 1395048-49-3, M-110
M-110
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
3106703 | 5 MG | 1220 | |||
3106703 | 25 MG | 4490 |
产品别名
1395048-49-3
M-110
2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
基本信息
Empirical Formula【经验(实验)分子式】 | C22H28ClN5O3 |
Molecular weight | 445.94 |
NACRES | NA.77 |
Biochem/physiol Actions【生化/生理作用】 | M-110 is a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3. M-110 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM. |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | powder |
color【颜色】 | white to beige |
solubility【溶解性】 | DMSO: 25 mg/mL, clear |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |