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MIP-1 beta from rat
产品编号: | 3114370 |
规格: | recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture |
包装规格: | 20 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
MIP-1 beta from rat
ACT-2
CCL4
基本信息
NACRES | NA.32 |
General description【一般描述】 | Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1a is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
Biochem/physiol Actions【生化/生理作用】 | Both MIP-1a and MIP-1b are structurally and functionally related CC chemokines. Recombinant rat MIP-1b is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
Sequence【序列】 | APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN |
Physical form【外形】 | Lyophilized with no additives. |
Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
产品性质
biological source【生物来源】 | rat |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
form【形式】 | lyophilized |
mol wt【分子量】 | 7.8 kDa |
packaging【包装】 | pkg of 20 μg |
technique(s) | cell culture | mammalian: suitable |
impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
color【颜色】 | white to off-white |
UniProt accession no.【UniProt登记号】 | P50230 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | rat ... CCL4(116637) |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |