2'-脱氧胞苷

C₉H₁₃N₃O₄

227.22

87567

213-454-1

MFCD00006547

24893793

NA.51

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

2′-Deoxycytidine has been used:

• as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
• as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
• to study the role of autophagy in response to oncogenes and DNA replication stress

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

200

synthetic (organic)

≥99% (HPLC)

powder

water: 50 mg/mL, clear, colorless to very faintly yellow

−20℃

NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2

1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

CKTSBUTUHBMZGZ-SHYZEUOFSA-N

1, 5 g in poly bottle
100, 250, 500 mg in poly bottle

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)