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ML239
产品别名
1378872-36-6
ML239
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H10Cl3N3O2 |
| Molecular weight | 346.60 |
| MDL number | MFCD23098913 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824724 |
| NACRES | NA.77 |
| Application【应用】 | ML239 has been used as a proble in cellular lipid profiling. |
| Biochem/physiol Actions【生化/生理作用】 | ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells. ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways. ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC50 of 1.16 μM with 24-fold selectivity against the control cell line. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 15 mg/mL (clear solution) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Clc1cc(Cl)c(OCC(=O)N\N=C\c2ccc[nH]2)c(Cl)c1 |
| InChI | 1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+ |
| InChI key | NVEDPFICKAIHKD-NGYBGAFCSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 + H312 + H332 - H315 - H319 - H335 - H400 |
| Precautionary Statements | P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
