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Monoclonal Anti-ACTN4 antibody produced in mouse
产品别名
Monoclonal Anti-ACTN4 antibody produced in mouse
FSGS1
ACTININ-4
FSGS
DKFZp686K23158
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. (provided by RefSeq) |
| Immunogen【免疫原】 | ACTN4 (NP_004915, 592 a.a. ~ 701 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence KEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYK |
| Physical form【外形】 | Clear solution |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | ascites fluid |
| antibody product type | primary antibodies |
| clone【克隆】 | 4D10, monoclonal |
| mol wt【分子量】 | antigen ~38.21 kDa |
| species reactivity | human, mouse, rat |
| technique(s) | indirect ELISA: suitable western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG2aκ |
| NCBI accession no.【NCBI登记号】 | NM_004924 |
| UniProt accession no.【UniProt登记号】 | O43707 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ACTN4(81) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
