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Monoclonal Anti-ALIX/PDCD6IP antibody produced in mouse
| 产品编号： | 3140813 |
| 规格： | clone ALIX-1, purified from hybridoma cell culture |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-ALIX/PDCD6IP antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma ALIX-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to an internal region of human ALIX/ PDCD6IP, conjugated to KLH. ALIX (Apoptosis-linked gene 2 (ALG-2)-interacting protein X), also named Programmed Cell Death 6 interacting protein (PDCD6IP). |
| Immunogen【免疫原】 | peptide corresponding to an internal region of human ALIX/ PDCD6IP |
| Application【应用】 | Monoclonal Anti-ALIX/PDCD6IP antibody has been used in
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| Biochem/physiol Actions【生化/生理作用】 | ALIX (Apoptosis-linked gene 2 (ALG-2)-interacting protein X) plays a role in ESCRT (endosomal sorting complexes required for transport) pathway. It is involved in the abscission stage of cytokinesis, in intralumenal endosomal localization, and in enveloped virus budding. Overexpression of this protein can block apoptosis. In addition, ALIX binds to PDCD6, a protein required for apoptosis, in a calcium-dependent manner. ALIX also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of ALIX and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | ALIX-1, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | flow cytometry: 5-10 μg/test using using human MOLT4 cells immunoblotting: 2-5 μg/mL using using whole extracts of human MOLT4 cells. immunofluorescence: 10-20 μg/mL using using human HeLa cells immunoprecipitation (IP): 10-20 μg/mL using using lysates of human MOLT4 cells. |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | Q8WUM4 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PDCD6IP(10015) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
