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Monoclonal Anti-CBLL1, (N-terminal) antibody produced in mouse

产品编号:3142207
规格:clone 3B12, purified immunoglobulin, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3142207100 μG5040
产品别名

Monoclonal Anti-CBLL1, (N-terminal) antibody produced in mouse

FLJ23109

MGC163401

MGC163403

HAKAI

RNF188

基本信息
NACRES
NA.41
General description【一般描述】
Epithelial cell cadherin (CDH1; MIM 192090) is endocytosed as a consequence of tyrosine phosphorylation and ubiquitination. HAKAI is an E3 ubiquitin ligase (see UBE3A; MIM 601623) that mediates ubiquitination of the CDH1 complex.[supplied by OMIM
Immunogen【免疫原】
CBLL1 (NP_079090, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGE
Application【应用】
Monoclonal Anti-CBLL1, (N-terminal) antibody produced in mouse is suitable for indirect ELISA and western blot analysis.
Biochem/physiol Actions【生化/生理作用】
CBLL1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase) is an E-cadherin binding protein involved in the ubiquitination of E-cadherin and regulation of E-cadherin complex endocytosis. During ubiquitination, it directly binds to the cytoplasmic domain of E-cadherin. It has been reported in a study that CBLL1 may play a role in neuronal apoptosis and in LPS (Lipopolysaccharide) administration. CBLL1 have also been predicted as a regulator of cell proliferation.
Physical form【外形】
Solution in phosphate buffered saline, pH 7.4
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
3B12, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~37.11 kDa
species reactivity
human
technique(s)
immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype【同位素/亚型】
IgG2aκ
NCBI accession no.【NCBI登记号】
NM_024814
UniProt accession no.【UniProt登记号】
Q75N03
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CBLL1(79872)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 1
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