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Monoclonal Anti-CEP164 antibody produced in mouse
产品别名
Monoclonal Anti-CEP164 antibody produced in mouse
Cep164 Antibody
NPHP15
Cep164 Antibody-Monoclonal Anti-CEP164 antibody produced in mouse
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The centrosomal protein 164 (CEP164) is expressed at the distal ends of the mother centriole. This protein consists of an N-terminal WW domain and three coiled-coil regions. The CEP164 gene is located on the human chromosome at 11q23.3. |
| Immunogen【免疫原】 | Human Cep164 |
| Application【应用】 | Monoclonal Anti-CEP164 antibody produced in mouse has been used in immunoblotting (5 μg/ml). |
| Biochem/physiol Actions【生化/生理作用】 | The centrosomal protein 164 (CEP164) plays an important role in the synthesis of the primary cilium. This protein interacts with several proteins during ciliogenesis such as Rabin-8, Tau tubulin kinase‐2 (TTBK2), coiled-coil domain containing 41 (CCDC41), and dishevelled (DVL). CEP164 protein is also involved in G2/M checkpoint and nuclear divisions. This protein is a key player in the DNA damage-activated ataxia telangiectasia mutated (ATM)/Rad3-related (ATR) signaling cascade since it is required for the proper phosphorylation of the histone family member X (H2AX), replication protein A (RPA), checkpoint kinase 1 and 2 (CHK1/2). Mutations in the CEP164 gene leads to a condition known as nephronophthisis (NPHP)‐ elated ciliopathies. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Phosphate-buffered saline, no preservative added. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 13 monoclonal |
| form【形式】 | liquid |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunocytochemistry: suitable immunofluorescence: suitable immunoprecipitation (IP): suitable western blot: 1:500-1:3000 |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | Q9UPV0 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CEP164(22897) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
