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Monoclonal Anti-CYBA antibody produced in mouse
| 产品编号： | 3143792 |
| 规格： | clone CB-64, purified from hybridoma cell culture |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-CYBA antibody produced in mouse
p22-PHOX
Cytochrome b558 subunit alpha
Superoxide-generating NADPH oxidase light chain subunit
cytochrome b-245 alpha polypeptide
Neutrophil cytochrome b 22 kDa polypeptide
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | CB-64, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | bovine, canine, monkey, human, mouse, rat |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | flow cytometry: 5-10 μg/test using HeLa cells. immunoblotting: 0.5-1 μg/mL using whole extracts of HeLa cells. immunofluorescence: 5-10 μg/mL using HeLa cells. |
| isotype【同位素/亚型】 | IgM |
| UniProt accession no.【UniProt登记号】 | P13498 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CYBA(1535) mouse ... Cyba(13057) rat ... Cyba(79129) |
基本信息
| General description【一般描述】 | Monoclonal Anti-CYBA (mouse IgM isotype) is derived from the hybridoma CB-64 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the internal region of human CYBA, conjugated to keyhole limpet hemocyanin (KLH). The small subunit, p22phox subunit, also known as cytochrome b245, alpha polypeptide/light chain (CYBA) is membrane bound,which is expressed in phagocytic, endothelial and vascular smooth muscle cells. This gene is located on human chromosome16q24 |
| Immunogen【免疫原】 | Synthetic peptide corresponding to a sequence at the internal region of human CYBA . |
| Application【应用】 | Monoclonal Anti-CYBA antibody produced in mouse has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | In prostate cancer cells downregulation of cytochrome b245, alpha polypeptide/light chain (CYBA) was reported to inhibited cell proliferation and colony formation, through AKT and ERK1/2 signaling pathways, indicating CYBA has a role in tumor angiogenesis and tumor growth. Mutations in this gene causes an autosomal recessive forms of chronic granulomatous disease (AR220CGD). |
| Physical form【外形】 | Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative. |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
