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Monoclonal Anti-E2F6 antibody produced in mouse
| 产品编号： | 3144363 |
| 规格： | ~1.0 mg/mL, clone TFE61, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-E2F6 antibody produced in mouse
Anti-E2F transcription factor 6
Anti-E2F-6
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | TFE61, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~35 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | immunocytochemistry: suitable indirect ELISA: suitable western blot: 2-4 μg/mL using HeLa nuclear cell extract |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | O75461 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... E2F6(1876) |
基本信息
| General description【一般描述】 | E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation. |
| Immunogen【免疫原】 | recombinant human E2F6 protein |
| Application【应用】 | Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract. |
| Biochem/physiol Actions【生化/生理作用】 | The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
