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Monoclonal Anti-GABRB3 antibody produced in mouse
| 产品编号： | 3145420 |
| 规格： | clone S87-25, 1 mg/mL, purified immunoglobulin |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-GABRB3 antibody produced in mouse
Anti-GABA(A) receptor subunit beta3
Anti-Gabrb3
Anti-GABAAR Beta3, S87-25
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family. |
| Specificity【特异性】 | Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1. |
| Immunogen【免疫原】 | Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502. |
| Biochem/physiol Actions【生化/生理作用】 | γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P). |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | S87-25, monoclonal |
| form【形式】 | buffered aqueous glycerol solution |
| mol wt【分子量】 | antigen predicted mol wt 55 kDa |
| species reactivity | mouse, human, rat |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NP_032097.1 |
| UniProt accession no.【UniProt登记号】 | P28472 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Gabrb3(14402) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
