您的位置：首页 > 产品中心 > Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal
Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal
| 产品编号： | 3146364 |
| 规格： | clone HDAC1-21, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal
Monoclonal Anti-Histone Deacetylase 1 (HDAC1) antibody produced in mouse
基本信息
| MDL number | MFCD01633420 |
| NACRES | NA.41 |
| General description【一般描述】 | Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the HDAC1-21 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human and mouse histone deacetylase 1 (HDAC1). Histone deacetylases (HDACs) are competing enzymes, belonging to histone deacetylase family. There are two classes of HDACs with six to seven different types of HDACs proteins. HDAC1,HDAC2 and HDAC3 belong to Class I HDACs and HDAC4, HDAC6, and HDAC7 belong to Class II HDACs. Class I HDACs consists of a single deacetylase domain at the N-termini and diversified C-terminal regions, while Class II contains a deacetylase domain at C-terminal position. |
| Application【应用】 | Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal has been used in:
|
| Biochem/physiol Actions【生化/生理作用】 | HDAC1 is widely studied and is shown to actively modulate the eukaryotic chromatin structure. It deacetylyses lysine residues on core histones (H2A, H2B, H3 and H4) at the N-terminal. It is a vital component of cofactor complexes and is involved in transcription regulation. Histone deacetylation results in transcription repression leading to the formation of tight nucleosomal structure which prevents DNA accessing. |
| Physical form【外形】 | solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | HDAC1-21, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~65 kDa |
| species reactivity | mouse, human |
| concentration【浓度】 | ~2 mg/mL |
| technique(s) | immunoprecipitation (IP): suitable indirect ELISA: suitable microarray: suitable western blot: 2-4 μg/mL using total cell extracts of HeLa cells |
| isotype【同位素/亚型】 | IgG3 |
| UniProt accession no.【UniProt登记号】 | Q13547 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HDAC1(3065) mouse ... Hdac1(433759) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
