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Monoclonal Anti-HLA Class I antibody produced in mouse
| 产品编号： | 3146392 |
| 规格： | clone MEM-81, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Human leukocyte antigen A classical class I family consists of three members including HLA-A, HLA-B and HLA-C. Members of classical class I major histocompatibility complex (MHC) contain a peptide bound to a transmembrane glycoprotein subunit, the heavy chain, in association with a soluble light chain called β2-microglobulin. Class I MHC are present in changeable volumes on all nucleated cells. The antibody MEM-81 reacts with human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types. |
| Immunogen【免疫原】 | Leukocytes of a patient suffering with LGL type leukemia |
| Application【应用】 | The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. |
| Biochem/physiol Actions【生化/生理作用】 | Human leukocyte antigen A class I downregulation is implicated in tumor invasion and development. Genetic variations in the class I major histocompatibility complex (MHC) is associated with the development of melanoma. HLA-viral peptide interaction plays a major role in the regulation of human immunodeficiency virus (HIV) infection. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | MEM-81, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | flow cytometry: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NM_002116.6 NM_002117.4 NM_005514.6 |
| UniProt accession no.【UniProt登记号】 | P01891 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| Gene Information | human ... HLA-A(3105), HLA-B(3106), HLA-C(3107) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
