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单克隆抗 HLA-DR 小鼠抗
Monoclonal Anti-HLA-DR antibody produced in mouse
| 产品编号： | 3146420 |
| 规格： | clone L243, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
单克隆抗 HLA-DR 小鼠抗
Monoclonal Anti-HLA-DR antibody produced in mouse
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The mouse monoclonal antibody L243 recognizes specifically HLA-DR molecules, both peptide-loaded and empty. Human leukocyte antigen (HLA)-DR is a member of HLA class II molecules. It is encoded by the gene mapped to human chromosome 6.(21} HLA class II molecules are highly expressed on B-Iymphocytes, but is also found at minimal levels on T-Iymphocytes, macrophages, thymus epithelial cells and selected cells of various body tissues. HLA-DR consists of a non-polymorphic α chain gene and up to three distinct highly polymorphic β chain genes. |
| Immunogen【免疫原】 | Human B lymphocytes |
| Application【应用】 | Monoclonal Anti-HLA-DR antibody produced in mouse has been used in double immunofluorescent staining. |
| Biochem/physiol Actions【生化/生理作用】 | Human leukocyte antigen (HLA)-DR activates a T-cell receptor by presenting antigenic peptides derived from extracellular proteins thus, stimulating an immune response against the antigen.{22] Mutation in the gene increases the risk of susceptibility to inflammatory bowel disease (IBD), Crohn′s disease and ulcerative colitis. Overexpression of monocytic (HLA)-DR has been observed in schizophrenic patients. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | L243, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | nonhuman primates, human, dog |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | FUNC: suitable flow cytometry: suitable immunoblotting: suitable immunocytochemistry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable |
| isotype【同位素/亚型】 | IgG2a |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
