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Monoclonal Anti-IDH1 antibody produced in mouse
产品别名
Monoclonal Anti-IDH1 antibody produced in mouse
Anti-IDH
Anti-NADP+-specific ICDH
Anti-NADP-dependent isocitrate dehydrogenase, cytosolic
Anti-IDP
Anti-Isocitrate dehydrogenase 1 (NADP+), soluble (IDH1)
Anti-Oxalosuccinate decarboxylase
Anti-IDPC
Anti-PICD
Anti-NADP-dependent isocitrate dehydrogenase, peroxisomal
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Isocitrate dehydrogenase 1 (IDH1) is encoded by the gene mapped to human chromosome 2q34. It is a member of the isocitrate dehydrogenase enzymes family. IDH1 is mainly found in cytoplasm and peroxisomes. |
| Immunogen【免疫原】 | IDH1 purified recombinant protein |
| Biochem/physiol Actions【生化/生理作用】 | Isocitrate dehydrogenase 1 (IDH1) acts as a regulator of cytoplasmic and peroxisomal lipid metabolism in various tissues. It catalyzes the conversion of isocitrate to α-ketoglutarate, which is a key cofactor for 2-OG-dependent dioxygenases. IDH1 facilitates various cellular processes such as adaptation to hypoxia, histone demethylation and DNA modification. It is also involved in the synthesis of plasmalogen lipids in peroxisomes. Somatic mutation of the gene is associated with the development of gliomas and acute myeloid leukaemia (AML). |
| Physical form【外形】 | Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | culture supernatant |
| antibody product type | primary antibodies |
| clone【克隆】 | IDH1-A36, monoclonal |
| form【形式】 | aqueous solution |
| mol wt【分子量】 | antigen predicted mol wt 46.7 kDa |
| species reactivity | human |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | O75874 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IDH1(3417) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
