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Monoclonal Anti-MBNL1 antibody produced in mouse
| 产品编号： | 3148244 |
| 规格： | ~1 mg/mL, clone HL 1822 (3A4-1E9), purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-MBNL1 antibody produced in mouse
Anti-EXP
Anti-CUG Triplet Repeat Expansion Double-stranded RNA-binding protein
Anti-Triplet-expansion RNA-binding protein
Anti-Muscleblind-like protein
Anti-KIAA0428
基本信息
| MDL number | MFCD09039233 |
| NACRES | NA.41 |
| General description【一般描述】 | Muscle blind-like 1 (MBNL1) is a homolog of human muscle blind like proteins. Proteins of the MBNL (muscleblind-like) family are mainly expressed in skeletal muscle neuronal tissues, thymus, liver and kidney. |
| Immunogen【免疫原】 | recombinant muscleblind-like1 (MBNL1) fusion protein. |
| Application【应用】 | Monoclonal Anti-MBNL1 antibody produced in mouse has been used in: immunoblotting, immunohistochemistry and immunocytochemistry |
| Biochem/physiol Actions【生化/生理作用】 | Proteins of the MBNL (muscleblind-like) family enhance inclusion or exclusion of specific exons on different pre-mRNAs by inhibiting the activity of CUG-BP and ETR-3-like factors (CELF proteins) bound to distinct intronic sites. MBNL1 may be implicated in the stimulation of muscle differentiation. Mice knockouts for the MBNL1 gene develop muscle, eye, and RNA splicing abnormalities that are characteristic of the neuromuscular disease myotonic dystrophy (DM) disease. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | HL 1822 (3A4-1E9), monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~42 kDa |
| species reactivity | mouse, human, monkey |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable microarray: suitable western blot: 0.2-0.5 μg/mL using HeLa nuclear cell extract |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | Q9NR56 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MBNL1(4154) mouse ... Mbnl1(56758) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
