Monoclonal Anti-Nebulin antibody produced in mouse

MFCD00164706

NA.41

Nebulin is also localized to cardiac muscle. Monoclonal Anti-Nebulin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Nebulin is a 700kDa protein which is expressed in skeletal muscles. It possesses 35 amino acid repeats and a C terminal serine-rich and SH3 domains.

Localizes nebulin in skeletal muscle of a wide variety of species from cold-blooded vertebrates to man. Does not crossreact with smooth or cardiac muscle, non-muscle tissue and cultured cells. Localizes nebulin within the I band of skeletal muscle sections by indirect immunofluorescence.

chicken breast nebulin.

Monoclonal Anti-Nebulin antibody produced in mouse has been used in:

• immunohistochemistry
• fluorescent immunostaining
• western blotting

Nebulin associates with the Z-line and thin actin filament in a sarcomere. It may function as a regulator of sarcomere thin filament length. The protein also acts as a structural link between sarcomeres. Nebulin interacts with the capping protein CapZ and has a role in controlling the localization of actin filaments.

200

mouse

unconjugated

ascites fluid

primary antibodies

NB2, monoclonal

antigen 500 kDa

15 mM sodium azide

vertebrates, chicken

indirect immunofluorescence: 1:400 using frozen sections of animal skeletal muscle
western blot: suitable

IgG1

dry ice

−20℃

chicken ... NEB(374027)

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12 - Non Combustible Liquids

WGK 3