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Anti-Nexilin antibody,Mouse monoclonal
| 产品编号： | 3149194 |
| 规格： | clone NX-38, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Nexilin antibody,Mouse monoclonal
Anti-Nelin
Anti-NEXN
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | NX-38, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 80 kDa |
| species reactivity | rat, human, mouse |
| packaging【包装】 | antibody small pack of 25 μL |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | immunocytochemistry: suitable western blot: 1-2 μg/mL using using rat brain S1 fraction extracts |
| isotype【同位素/亚型】 | IgG2a |
| UniProt accession no.【UniProt登记号】 | Q0ZGT2 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... NEXN(91624) mouse ... Nexn(68810) rat ... Nexn(246172) |
基本信息
| General description【一般描述】 | Monoclonal Anti-Nexilin (mouse IgG2a isotype) is derived from the hybridoma NX-38 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide conjugated to KLH. Nexilin is a filamentous actin-binding protein that localizes to focal contacts. Alternative splicing of the gene yields two different isoforms namely, b-nexilin and s-nexilin. NEXN (nexilin), a cardiac Z-disc protein is made of 675 amino acids. It is present in the heart and skeletal muscle. NEXN is mapped to human chromosome 1p31. |
| Specificity【特异性】 | Monoclonal Anti-Nexilin recognizes human, rat, and mouse nexilin. |
| Application【应用】 | Anti-Nexilin antibody,Mouse monoclonal may be used in immunoblotting and immunocytochemistry. |
| Biochem/physiol Actions【生化/生理作用】 | NEXN (nexilin) plays an important role in protecting cardiac Z-discs from forces generated within the sarcomere. Mutations in NEXN results in hypertrophic cardiomyopathy. Nexilin may be involved in cell adhesion and migration. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品说明
| Storage and Stability【储存及稳定性】 | Store at –20 ℃. For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze at –20 ℃ in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
