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Monoclonal Anti-PIAS3 小鼠抗

Monoclonal Anti-PIAS3 antibody produced in mouse
产品编号:3150243
规格:~2 mg/mL, clone PIA3, purified immunoglobulin, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3150243200 μL4730
产品别名

Monoclonal Anti-PIAS3 小鼠抗

Monoclonal Anti-PIAS3 antibody produced in mouse

Anti-Protein Inhibitor of Activated STAT 3

基本信息
MDL number
MFCD09265430
NACRES
NA.41
General description【一般描述】
Protein inhibitor of activated STAT protein 3 (PIAS3) is an inhibitor of activated STAT3. The gene encodes for a 619-amino acid protein and has a molecular mass of 68 kDa. PIAS3 shares 55% identity with PIAS1 and PIASX proteins and 39% identity with PIASY. PIAS3 is widely expressed in various human tissues.
Immunogen【免疫原】
synthetic peptide corresponding to amino acids 591-604 of human PIAS3.
Application【应用】
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Monoclonal Anti-PIAS3 antibody produced in mouse has been used in:
  • enzyme linked immuno sorbent assay (ELISA)
  • immunoblotting
  • immunocytochemistry

Biochem/physiol Actions【生化/生理作用】
Protein inhibitor of activated STAT protein 3 (PIAS3) and other members of this family can act as small ubiquitin-like modifier (SUMO) E3 ligases and interfere with the transcription activity of many transcription factors. PIAS3 binds to microphthalmia-associated transcription factor (MITF), a key DNA-binding protein. It blocks MITF DNA-binding activity and co-expression of MITF. PIAS3 in NIH 3T3 cells inhibits MITF-driven transcription activity.
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
PIA3, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~68 kDa (additional band at 44 kDa may be present)
species reactivity
mouse, chicken, bovine, human, canine
concentration【浓度】
~2 mg/mL
technique(s)
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using HepG2 total cell extract
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
Q9Y6X2
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PIAS3(10401)
mouse ... Pias3(229615)
产品说明
Target description【目标描述】
PIAS3 encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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