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Anti-Podoplanin antibody, RAT monoclonal
产品编号: | 3150450 |
规格: | clone NZ-1.2, purified from hybridoma cell culture |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-Podoplanin antibody, RAT monoclonal
Anti-GP36, glycoprotein, 36-KD
Anti-GP40
Anti-AGGRUS
Anti-T1A-2
Anti-Gp38
Anti-OTS8
Anti-T1A
基本信息
NACRES | NA.41 |
General description【一般描述】 | Monoclonal Anti-Podoplanin (rat IgG2a isotype) is derived from the hybridoma NZ-1.2 produced by the fusion of mouse myeloma cells and splenocytes from CD rat immunized with platelet-aggregation-stimulating (PLAG) domain of podoplanin. Podoplanin (Aggrus) is an integral membrane mucoprotein present on the surface of podocytes in kidney glomeruli and the parietal cells of the glomerular Bowman′s capsule. It is a single membrane-spanning protein composed of a heavily glycosylated extracellular domain and a short intracytoplasmic tail. The extracellular domain possesses a platelet aggregation stimulating (PLAG) domain. Podoplanin has been described to be present in normal, inflammatory and neoplastic lymphatic capillary endothelium. |
Immunogen【免疫原】 | platelet-aggregation-stimulating (PLAG) domain of human podoplanin. |
Application【应用】 | Anti-Podoplanin antibody, Mouse monoclonal has been used in:
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper) Western Blotting (1 paper) |
Biochem/physiol Actions【生化/生理作用】 | Expression of podoplanin is regulated by the lymphatic-specific homeobox gene Prox-1 (prospero-1). It is involved in lymphatic vessel formation and might be associated with tissue development and repair. Podoplanin is detected in human angiosarcomas, lymphangiomas, and in Kaposi′s sarcomas. It is implicated in the onset of tumor invasion, metastasis or malignant progression. Podoplanin plays an important role in the maintenance of podocyte foot processes and glomerular permeability. |
Physical form【外形】 | 0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。 |
产品性质
Quality Level【质量水平】 | 200 |
biological source【生物来源】 | rat |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified from hybridoma cell culture |
antibody product type | primary antibodies |
clone【克隆】 | NZ-1.2, monoclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~36 kDa |
species reactivity | human |
concentration【浓度】 | ~1.5 mg/mL |
technique(s) | flow cytometry: suitable immunocytochemistry immunoprecipitation (IP): suitable western blot: 4-8 μg/mL using U87 total cell extract |
UniProt accession no.【UniProt登记号】 | Q86YL7 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... PDPN(10630) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |