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Anti-PSMA antibody, Mouse monoclonal
| 产品编号： | 3150858 |
| 规格： | clone 107-1A4, purified from hybridoma cell culture |
| 包装规格： | 25 μL，100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PSMA antibody, Mouse monoclonal
PSMA Antibody-Monoclonal Anti-PSMA antibody produced in mouse
Monoclonal Anti-N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE 1
Monoclonal Anti-NAALAD
Monoclonal Anti-GCP2
Monoclonal Anti-GLUTAMATE CARBOXYPEPTIDASE II
Monoclonal Anti-PSM
Monoclonal Anti-FOLATE HYDROLASE 1
Monoclonal Anti-FOLH1
Monoclonal Anti-PROSTATE-SPECIFIC MEMBRANE ANTIGEN
Psma Antibody
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1 (FOLH1), is a 100kDa membrane glycoprotein, composed of 750 amino acids. PSMA gene with 19 exons and 18 introns is mapped to human chromosome 11p11–12. The encoded protein is detected in various type of tissues including kidney, prostate and brain. PSMA contains short cytoplasmic amino terminus, a single membrane-spanning domain and a large extracellular domain. Monoclonal Anti-PSMA (mouse IgG1 isotype) is derived from the hybridoma 107-1A4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Prostate-specific membrane antigen (PSMA) is an integral, non-shed, type 2 transmembrane glycoprotein belonging to the M28 peptidase family. |
| Immunogen【免疫原】 | prostate cancer LNCaP cells. |
| Application【应用】 | Monoclonal Anti-PSMA antibody produced in mouse has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Prostate-specific membrane antigen (PSMA), expressed in the brain, catalyzes the hydrolysis of N-acetyl-aspartyl glutamate to produce free glutamate. Elevated expression of the protein is associated with the development of prostate tumor. Mutations in PSMA leads to hyperhomocysteinemia. PSMA functions as a potential biomarker of prostate adenocarcinoma. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 107-1A4, monoclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| packaging【包装】 | antibody small pack of 25 μL |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | flow cytometry: suitable immunocytochemistry: suitable immunoprecipitation (IP): suitable indirect ELISA: suitable indirect immunofluorescence: 5-10 μg/mL using methanol/acetone fixed LNCaP cells. |
| isotype【同位素/亚型】 | IgG1 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
