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Anti-SATB1 antibody, Mouse monoclonal

产品编号:3151859
规格:clone SAT-5, purified from hybridoma cell culture
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3151859200 μL5000
产品别名

Anti-SATB1 antibody, Mouse monoclonal

Anti-Special AT-rich sequence-binding protein 1

Anti-SATB homeobox 1

Monoclonal Anti-SATB1 antibody produced in mouse

基本信息
NACRES
NA.41
General description【一般描述】
Monoclonal Anti-SATB1 (mouse IgG2a isotype) is derived from the hybridoma SAT-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the N-terminus of human special AT-rich sequence-binding protein 1 (SATB1), conjugated to keyhole limpet hemocyanin (KLH). SATB1 encodes as nuclear matrix protein that interacts with scaffold-associating DNA. SATB1 gene is mapped to human chromosome 3p24.3.
Immunogen【免疫原】
a synthetic peptide corresponding to a sequence at the N-terminus of human SATB1, conjugated to KLH.
Application【应用】
Monoclonal Anti-SATB1 antibody produced in mouse has been used in:
  • immunoblotting
  • immunocytochemistry
  • flow cytometry

Biochem/physiol Actions【生化/生理作用】
Special AT-rich sequence-binding protein 1 (SATB1) is a tumor promotor gene that plays an important role in regulating gene expression. The SATB1 known to be involved in organizing higher-order chromatin structure including the subnuclear organization of individual genes within multigene clusters in a tissue specific manner, locally and at a distance. It controls the global chromatin architecture via promyelocytic leukemia protein (PML). SATB1 also regulates the periodic anchoring of matrix attachment regions (MARs) in DNA to the nuclear matrix. This organizes chromatin into distinct loops. Furthermore, SATB1 recruits co-repressor complexes to its binding sites. SATB1 is abnormally expressed in human metastatic breast cancer and also promotes breast cancer tumor growth and metastasis. It is involved in the tumorigenesis of colorectal, coetaneous malignant melanoma and lung cancers. SATB1 also serves as a possible prognostic marker.
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified from hybridoma cell culture
antibody product type
primary antibodies
clone【克隆】
SAT-5, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~100 kDa
species reactivity
human, mouse, rat, monkey
concentration【浓度】
~1.0 mg/mL
technique(s)
flow cytometry: 5-10 μg using THP-1 cells
immunocytochemistry: suitable
western blot: 2.0-4.0 μg/mL using Jurkat total cell extracts
UniProt accession no.【UniProt登记号】
Q01826
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... SATB1(6304)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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