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Anti-SFPQ antibody, Mouse monoclonal

产品编号:3152042
规格:clone FC23, purified from hybridoma cell culture
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3152042200 μL5040
产品别名

Anti-SFPQ antibody, Mouse monoclonal

Monoclonal Anti-SFPQ antibody produced in mouse

基本信息
NACRES
NA.41
General description【一般描述】
Splicing factor proline and glutamine rich (SFPQ), also known as polypyrimidine tract-binding protein-associated-splicing factor (PSF), is a multifunctional nuclear protein. It is encoded by the gene mapped to human chromosome 1p34. The encoded protein is characterized with an N-terminal glycine rich domain, a proline/glutamine-rich domain (P/Q), two RNA recognition motifs (RRMs) and a C-terminal region with two nuclear localization signals.
Splicing factor, praline- and glutamine-rich (SFPQ), also known as PSF, is a member of the DBHS (Drosophila behaviour, human splicing) protein family, consisting also of PSPC1 (paraspeckle protein 1) and NONO (non-POU-domain-containing, octamer binding protein). The DBHS proteins localizes between the nucleoplasm, paraspeckles and the nucleolus. Monoclonal Anti-SFPQ (mouse IgG2a isotype) is derived from the hybridoma FC23 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the C-terminal region of mouse SFPQ, conjugated to keyhole limpet hemocyanin (KLH).
Immunogen【免疫原】
Synthetic peptide corresponding to a sequence at the C-terminal region of mouse SFPQ, conjugated to KLH. The corresponding sequence is identical in rat and human.
Application【应用】
Monoclonal Anti-SFPQ antibody produced in mouse has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions【生化/生理作用】
Drosophila behaviour, human splicing (DBHS) proteins are involved in several biological processes such as regulation of circadian rhythm, carcinogenesis and cancer progression. SFPQ activates androgen receptor mediated transcription.
Splicing factor proline and glutamine rich (SFPQ) along with its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), plays a vital role in RNA processing, RNA splicing and transcriptional regulation. Additionally, these proteins also play a crucial role in various regulatory roles including, selective nuclear retention of defective mRNAs. SFPQ participates in transcription repression by recruiting transcription regulator proteins Sin3a and histone deacetylase (HDAC).
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified from hybridoma cell culture
antibody product type
primary antibodies
clone【克隆】
FC23, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~95 kDa
species reactivity
rat, mouse, human
concentration【浓度】
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 10-20 μg/mL using HeLa cells.
western blot: 0.5-1 μg/mL using Whole extracts of mouse Hepa1-6 cells.
isotype【同位素/亚型】
IgG2a
UniProt accession no.【UniProt登记号】
P23246
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... SFPQ(6421)
mouse ... Sfpq(71514)
rat ... Sfpq(252855)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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