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Monoclonal Anti-Strumpellin antibody produced in mouse
| 产品编号： | 3152850 |
| 规格： | clone St-1, purified from hybridoma cell culture |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The gene KIAA0196 (strumpellin) is mapped to human chromosome 8q24. It is a widely expressed gene and the protein localizes in the cytoplasm and endoplasmic reticulum. Monoclonal Anti-Strumpellin (mouse IgG1 isotype) is derived from the hybridoma St-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal region of human Strumpellin, conjugated to KLH. |
| Immunogen【免疫原】 | synthetic peptide corresponding to an internal region of human Strumpellin. |
| Application【应用】 | Monoclonal Anti-Strumpellin antibody has been used in
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| Biochem/physiol Actions【生化/生理作用】 | Strumpellin, causes hereditary spastic paraplegia, a progressive neurodegenerative disorder clinically characterized by central motor system deficits leading to spastic paraparesis of the lower limbs. Strumpellin presence was observed in protein aggregate diseases affecting striated muscles and the Central nervous system (CNS). KIAA0196 (strumpellin) is involved in the WASH (WASP and Scar homologue) complex, an actin-regulating complex. It works as an interlink between actin regulation and endosomal membrane dynamics. Mutations in KIAA0196 are associated with spastic paraplegia and RSS (Ritscher-Schinzel syndrome). |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | St-1, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~120 kDa |
| species reactivity | mouse, human, rat |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | flow cytometry: 10-20 μg/test using using HeLa cells. immunoblotting: 2.5-5 μg/mL immunoprecipitation (IP): 5-10 μg using using lysates of rat A10 cells. |
| isotype【同位素/亚型】 | IgG1 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... KIAA0196(9897) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
