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Anti-STUB1/CHIP antibody, mouse monoclonal
| 产品编号： | 3152853 |
| 规格： | clone ST21.55, purified from hybridoma cell culture |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-STUB1/CHIP antibody, mouse monoclonal
Anti-STIP1 homologous and box-containing protein 1 (STUB1)
Anti-HSPABP2
Anti-Serologically defined colon cancer antigen 7
Anti-C terminus of HSC70-interacting protein (CHIP)
Anti-Heat shock protein A binding protein 2 (c-terminal)
Anti-UBOX1
Anti-NY-CO-7
Anti-SDCCAG7
基本信息
| MDL number | MFCD02262541 |
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-STUB1/CHIP (mouse IgG2b isotype) is derived from the hybridoma ST21.55 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids 30-45 of human STUB1/CHIP. STUB1/CHIP (carboxyl terminus of Hsc70-interacting protein) consists of three functional domains: a tetratricopeptide repeat (TRP) at the amino terminus, a U- box domain at the C-terminus, and a highly charged region separating the two. STUB1 (STIP1 homology and U-box containing protein 1) or CHIP (carboxyl terminus of Hsc70- interacting protein) is an E3 ubiquitin ligase, (2) that is located on human chromosome 16p13.3. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 30-45 of human STUB1/CHIP. |
| Application【应用】 | Anti-STUB1/CHIP antibody, mouse monoclonal has been used in immunoblotting and enzyme-linked immunosorbent assay (ELISA). |
| Biochem/physiol Actions【生化/生理作用】 | In lens epithelial cells, knocking down CHIP (carboxyl terminus of Hsc70- interacting protein) decreased the reaction of heat shock and potential of protein quality control. It plays a major role in neurodegeneration and also controls autophagic flux. It can deactivate NF-κB signaling and damage the capability of migration and invasion in gastric cancer cells. STUB1/CHIP (carboxyl terminus of Hsc70-interacting protein) is such a cofactor, which interacts, among others, with Hsc70 and acts as a U-box-dependent E3 ubiquitin ligase. STUB1/CHIP can also act as a direct chaperone of p53, both under physiological and stress conditions. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | ST21.55, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~35 kDa |
| species reactivity | bovine, human, rat |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | indirect ELISA: suitable western blot: 2.5-5 μg/mL using HeLa total cell extract. |
| isotype【同位素/亚型】 | IgG2b |
| UniProt accession no.【UniProt登记号】 | Q9UNE7 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | bovine ... STUB1(504565) human ... STUB1(10273) mouse ... Stub1(56424) rat ... Stub1(287155) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
