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N-(3-Pyridyl)indomethacinamide
产品别名
261766-29-4
N-(3-Pyridyl)indomethacinamide
N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
N-3PyIA
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H20N3O3Cl |
| Molecular weight | 433.89 |
| MDL number | MFCD02683393 |
| PubChem Substance ID【PubChem化学物质编号】 | 329820062 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Potent and selective reversible cyclooxygenase-2 (COX-2) inhibitor (IC50 = 0.1 μM, human recombinant); about 300-fold less potent as an inhibitor of human recombinant COX-1. Not as selective with natural ovine COX (IC50 = 75 μM for COX-1 and 50 μM for COX-2). |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% |
| form【形式】 | powder |
| solubility【溶解性】 | chloroform: 10 mg/mL to clear, colorless to light yellow |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | COc1ccc2n(c(C)c(CC(=O)Nc3cccnc3)c2c1)C(=O)c4ccc(Cl)cc4 |
| InChI | 1S/C24H20ClN3O3/c1-15-20(13-23(29)27-18-4-3-11-26-14-18)21-12-19(31-2)9-10-22(21)28(15)24(30)16-5-7-17(25)8-6-16/h3-12,14H,13H2,1-2H3,(H,27,29) |
| InChI key | DTAPHQYAZUTCIG-UHFFFAOYSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
