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N-Butyldeoxynojirimycin

产品编号:3169747
规格:film (dried in situ)
CAS NO:72599-27-0
包装规格:1 MG,5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
31697471 MG4800
31697475 MG17860
产品别名

72599-27-0

N-Butyldeoxynojirimycin

Miglustat

NB-DNJ

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C10H21NO4
Molecular weight
219.28
MDL number
MFCD00272581
PubChem Substance ID【PubChem化学物质编号】
24892070
NACRES
NA.32
General description【一般描述】
N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.
Application【应用】
N-Butyldeoxynojirimycin has been used:
  • in the inhibition of glycolipid synthesis in neuroblastoma cells
  • in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
  • in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Biochem/physiol Actions【生化/生理作用】
N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.
α-glucosidase Inhibitor
产品性质
Assay【测定】
≥98% (TLC)
Quality Level【质量水平】
200
form【形式】
film (dried in situ)
solubility【溶解性】
water: 9.80-10.20 mg/mL, clear, colorless
storage temp.【储存温度】
2-8℃
SMILES string
CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
InChI key
UQRORFVVSGFNRO-UTINFBMNSA-N
Gene Information
human ... UGCG(7357)
packaging【包装】
1, 5 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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