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Nα-甲基组胺 二盐酸盐

Nα-Methylhistamine dihydrochloride
产品编号:3171910
规格:solid
CAS NO:16503-22-3
包装规格:10 MG,50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
317191010 MG2180
317191050 MG6140
产品别名

16503-22-3

Nα-甲基组胺 二盐酸盐

Nα-Methylhistamine dihydrochloride

NAMH dihydrochloride

N-Methyl-1H-imidazole-4-ethanamine dihydrochloride

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C6H11N3 · 2HCl
Molecular weight
198.09
MDL number
MFCD00134838
PubChem Substance ID【PubChem化学物质编号】
24724503
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
Nα-Methylhistamine dihydrochloride helps in removing or decreasing the headache in migraine prophylaxis. It is highly effective than histamine in inducing cyclic adenosine 3′,5′-monophosphate (cAMP) synthesis.
Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.
Features and Benefits【特点和优势】
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
Quality Level【质量水平】
100
Assay【测定】
(The product is pure based on elemental analysis results, NMR and MS spectra.)
form【形式】
solid
color【颜色】
white
solubility【溶解性】
H2O: >20 mg/mL
storage temp.【储存温度】
2-8℃
SMILES string
Cl[H].Cl[H].CNCCc1c[nH]cn1
InChI
1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
InChI key
AYUQICXJAMPXPF-UHFFFAOYSA-N
packaging【包装】
10, 50 mg in glass bottle
安全信息
Pictograms【象形图】
GHS05,GHS07
Signal word【警示用语:】
Danger
Hazard Statements
H302 - H315 - H318 - H335
Precautionary Statements
P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
Hazard Classifications【危险分类】
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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