NPS2143 hydrochloride

C₂₄H₂₅ClN₂O₂ · HCl

445.38

MFCD16038896

329825364

NA.77

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

• In the regulation of intestinal calcium transport.
• In the regulation of local negative feedback of intestinal calcium absorption.
• In sensorimotor decision making during development.

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

100

≥98% (HPLC)

powder

[α]20/D +20 to +24°, c = 1.0 in methanol

white to beige

DMSO: >10 mg/mL

2-8℃

Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N

1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1

ZEBNDUQLNGYBNL-VEIFNGETSA-N

5, 25 mg in glass bottle

GHS07,GHS09

Warning

H302 + H312 + H332 - H410

P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

11 - Combustible Solids

WGK 3