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NSC43067
产品别名
26903-26-4
NSC43067
1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one
NSC 43067
1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H12OS |
| Molecular weight | 228.31 |
| MDL number | MFCD00489751 |
| PubChem Substance ID【PubChem化学物质编号】 | 329818472 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible. |
| Features and Benefits【特点和优势】 | This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | light yellow to light tan |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cc1ccc(s1)C(=O)\C=C\c2ccccc2 |
| InChI | 1S/C14H12OS/c1-11-7-10-14(16-11)13(15)9-8-12-5-3-2-4-6-12/h2-10H,1H3/b9-8+ |
| InChI key | AOUMOFQEBZGSPD-CMDGGOBGSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H413 |
| Precautionary Statements | P264 - P270 - P273 - P301 + P312 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Chronic 4 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
