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PF 3845 hydrate

产品编号:3180537
规格:≥98% (HPLC)
CAS NO:1196109-52-0
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
31805375 MG1380
318053725 MG5070
产品别名

1196109-52-0

PF 3845 hydrate

N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide hydrate

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C24H23F3N4O2 · xH2O
Molecular weight
456.46 (anhydrous basis)
MDL number
MFCD21365072
PubChem Substance ID【PubChem化学物质编号】
329823740
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
PF 3845 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. The endocannabinoid system is a target for therapeutic pain relief. PF-3845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It high selectivity over other enzymes including FAAH-2. In mouse studies, PF-3845 has been shown to raise brain anandamide levels for up to 24 hr; and in a rat model it produced significant reduction of inflammatory pain..
Other Notes【其他说明】
This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information【法律信息】
Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
manufacturer/tradename
Pfizer®
storage condition【储存条件】
desiccated
color【颜色】
white to tan
solubility【溶解性】
DMSO: ≥45 mg/mL
originator【创始人】
Pfizer
storage temp.【储存温度】
2-8℃
SMILES string
O.FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc4cccnc4)c2)nc1
InChI
1S/C24H23F3N4O2.H2O/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20;/h1-7,10,14-17H,8-9,11-13H2,(H,30,32);1H2
InChI key
CVQMBUCCSAKASE-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Pictograms【象形图】
GHS06
Signal word【警示用语:】
Danger
Hazard Statements
H301
Precautionary Statements
P301 + P310
Hazard Classifications【危险分类】
Acute Tox. 3 Oral
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
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