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PF-04691502
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3180559 | 5 MG | 1220 | |||
| 3180559 | 25 MG | 4490 |
产品别名
1013101-36-4
PF-04691502
2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one
PF-4691502
PF04691502
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H27N5O4 |
| Molecular weight | 425.48 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823786 |
| Biochem/physiol Actions【生化/生理作用】 | PF-04691502 is a potent dual mTOR/PI3K inhibitor with Ki values of 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, β, γ, and mTOR, respectively, with no significant inhibitory activity at more than 80 other protein kinases, including PI 3-K downstream kinases, and MAPK family members. PF-04691502 showed antitumor activity in several non-small cell lung carcer (NSCLC) xenografts and ovarian cancer cell lines. PF-04691502 is currently in clinical trials. |
| Other Notes【其他说明】 | This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | , white to yellow to light brown |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | room temp |
| SMILES string | CC1=C(C(N([C@H]2CC[C@H](OCCO)CC2)C3=O)=NC(N)=N1)C=C3C4=CN=C(OC)C=C4 |
| InChI | 1S/C22H27N5O4/c1-13-17-11-18(14-3-8-19(30-2)24-12-14)21(29)27(20(17)26-22(23)25-13)15-4-6-16(7-5-15)31-10-9-28/h3,8,11-12,15-16,28H,4-7,9-10H2,1-2H3,(H2,23,25,26)/t15-,16- |
| InChI key | XDLYKKIQACFMJG-WKILWMFISA-N |
| Gene Information | human ... MTOR(2475), PIK3CA(5290), PIK3CB(5291), PIK3CD(5293), PIK3CG(5294), PIK3R1(5295), PIK3R2(5296), PIK3R3(8503), PIK3R5(23533) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
