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PF-956980 hydrate
产品别名
PF-956980 hydrate
{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-pyrrolidin-1-yl-methanone hydrate
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C18H26N6O · xH2O |
Molecular weight | 342.44 (anhydrous basis) |
MDL number | MFCD18452852 |
PubChem Substance ID【PubChem化学物质编号】 | 329823736 |
NACRES | NA.77 |
Biochem/physiol Actions【生化/生理作用】 | PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist. |
Features and Benefits【特点和优势】 | This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
Other Notes【其他说明】 | This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | powder |
optical activity【旋光性】 | [α]/D +33 to +40°, c = 0.5 in methanol |
manufacturer/tradename | Pfizer® |
color【颜色】 | white to off-white |
solubility【溶解性】 | DMSO: ≥50 mg/mL |
originator【创始人】 | Pfizer |
storage temp.【储存温度】 | 2-8℃ |
SMILES string | O.C[C@@H]1CCN(C[C@@H]1N(C)c2ncnc3[nH]ccc23)C(=O)N4CCCC4 |
InChI | 1S/C18H26N6O.H2O/c1-13-6-10-24(18(25)23-8-3-4-9-23)11-15(13)22(2)17-14-5-7-19-16(14)20-12-21-17;/h5,7,12-13,15H,3-4,6,8-11H2,1-2H3,(H,19,20,21);1H2/t13-,15+;/m1./s1 |
InChI key | VZUKSTKLTSSYKP-PBCQUBLHSA-N |
packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
Pictograms【象形图】 | GHS06 |
Signal word【警示用语:】 | Danger |
Hazard Statements | H301 + H311 + H331 |
Precautionary Statements | P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311 |
Hazard Classifications【危险分类】 | Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral |
Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
WGK | WGK 3 |