您的位置：首页 > 产品中心 > 101246-66-6， Phenserine
Phenserine
| 产品编号： | 3180992 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 101246-66-6 |
| 包装规格： | 25 MG，100 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
101246-66-6
Phenserine
(-)-N-Phenylcarbamoyleseroline
1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol phenylcarbamate (ester)
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H23N3O2 |
| Molecular weight | 337.42 |
| MDL number | MFCD00672748 |
| PubChem Substance ID【PubChem化学物质编号】 | 329820018 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | (-)-Phenserine, a phenylcarbamate derivative, is a selective, non-competitive inhibitor of acetylcholinesterase (AChE). (-)-Phenserine produces rapid, potent, and long-lasting AChE inhibition, in vivo. It is significantly less toxic than (-)-physostigmine. (-)-Phenserine improves cognitive performance in both young learning-impaired and elderly rats. Reduced secretion of β-amyloid (Abeta) has been observed in cell lines exposed to (-)-phenserine, occurring through translational regulation of β-amyloid precursor protein (beta-APP) mRNA via a non-cholinergic mechanism. These in vitro findings appear to translate in vivo into animal models and humans. |
| Features and Benefits【特点和优势】 | This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | off-white |
| solubility【溶解性】 | H2O: <2 mg/mL DMSO: >5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | [H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)Nc4ccccc4)ccc3N2C |
| InChI | 1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m1/s1 |
| InChI key | PBHFNBQPZCRWQP-QUCCMNQESA-N |
| packaging【包装】 | 25, 100 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
