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PMEG hydrate
产品别名
PMEG hydrate
9-[2-(Phosphonomethoxy)ethyl]guanine hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H12N5O5P · xH2O |
| Molecular weight | 289.19 (anhydrous basis) |
| MDL number | MFCD19443863 |
| PubChem Substance ID【PubChem化学物质编号】 | 329817932 |
| Biochem/physiol Actions【生化/生理作用】 | The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: ≥5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1 |
| InChI | 1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2 |
| InChI key | BDVQXHFCXJXVND-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
