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PQ401

产品编号:3190645
规格:≥98% (HPLC), powder
CAS NO:196868-63-0
包装规格:10 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
319064510 MG2220
产品别名

196868-63-0

PQ401

N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea

IGF-1R Inhibitor II

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C18H16ClN3O2
Molecular weight
341.79
MDL number
MFCD00160558
PubChem Substance ID【PubChem化学物质编号】
24724567
NACRES
NA.77
Application【应用】
PQ401 has been used as:
  • an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression
  • a reference inhibitor in dose-response measurements studies
  • an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition

Biochem/physiol Actions【生化/生理作用】
PQ401, a diaryl urea compound that serves as an anti-glioma agent.
PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
Features and Benefits【特点和优势】
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white
solubility【溶解性】
DMSO: >10 mg/mL
H2O: <2 mg/mL
storage temp.【储存温度】
2-8℃
SMILES string
COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23
InChI
1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
InChI key
YBLWOZUPHDKFOT-UHFFFAOYSA-N
packaging【包装】
10 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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